LEE, YIH-JING Professor
yjlee@mail.fju.edu.tw |
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Education
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Ph.D. in Physiology, Kings College London, United Kingdom |
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Experience
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Professor, School of Medicine, Fu-Jen Catholic University
Vice Dean, Office of Research and Development, Fu-Jen Catholic University
Director, Center of Research Ethics, Fu-Jen Catholic University
Director, Center of Research Management, Fu-Jen Catholic University
Associate Professor, School of Medicine, Fu-Jen Catholic University
Assistant Professor, School of Medicine, Fu-Jen Catholic University
Research Associate, Department of Pharmacology, University of Cambridge, United Kingdom |
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Specialty
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Physiology; Neuroscience; Neurophysiology; Retinal physiology; Stem cell applications |
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Author
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Journal Paper
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Guo SL, Chin CH, Huang CJ, Chien CC, and Lee YJ* (2022): Promotion of the differentiation of dental pulp stem cells into oligodendrocytes by knockdown of heat-shock protein 27. Developmental Neuroscience, DOI: 10.1159/000521744. (SCI) |
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Cheng YC, Huang CJ, Ku WC, Guo SL, Tien LT, Lee YJ*, and Chien CC* (2022): Downregulated calcium‐binding protein S100A16 and HSP27 in placenta‐derived multipotent cells induce functional astrocyte differentiation. Stem Cell Reviews and Reports, DOI: 10.1007/s12015-021-10319-3. (SCI) |
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Hsieh CT, Lee YJ, Lee JW, Lu S, Tucci MA, Dai X, Ojeda NB, Lee HJ, Fan LW, and Tien LT* (2020): Interleukin-1 receptor antagonist ameliorates the pain hypersensitivity, spinal inflammation and oxidative stress induced by systemic lipopolysaccharide in neonatal rats. Neurochemstry International, 135: 104686. (SCI) |
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Lee YJ*, Ke CY, Tien N, and Lin PK* (2018): Hyperhomocysteinemia causes chorioretinal angiogenesis with placental growth factor upregulation. Scientific Reports, 8:15755. (SCI) |
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Chang JS, Lee YJ, Wilkie DA, Lin CT* (2018): The neuroprotective and antioxidative effects of submicron and blended Lycium barbarum in experimental retinal degeneration in rats. Journal of Veterinary Medical Science, 80(7): 1108–1115. (SCI, equal contribution to ChangJS and LeeYJ) |
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Fan HC, Chi CS, Lee YJ, Tsai JD, Lin SZ, and Harn HJ* (2017): The role of gene editing in neurodegenerative diseases. Cell Transplantation, 27(3): 364-378 (SCI) |
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Chien CC, Lim YT, Tien LT, and Lee YJ* (2018): Subretinal-transplanted umbilical mesenchymal stem cells express retinal cell markers and reverse retinal function loss in a light-induced retinopathy model. Fu-Jen Journal of Medicine, 16(1): 1-15. |
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Lee YJ, Chiu CC, Ke CY, Tien N, and Lin PK* (2017): Homocysteine facilitates prominent polygonal angiogenetic networks of a choroidal capillary sprouting model. Investigative Ophthalmology & Visual Science, 58(10):4332-4343. (SCI) |
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Tien LT, Lee YJ, Pang Y, Lu S, Lee JW, Tseng CH, Bhatt AJ, Savich RD, and Fan LW* (2017): Neuroprotective effects of intranasal IGF-1 against neonatal lipopolysaccharide-induced meurobehavioral deficits and neuronal inflammation in the substantia nigra and locus coeruleus of juvenile rats. Developemntal Neuroscience, 39(6):443-459 (SCI) |
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Chien CC, Huang CJ, Tien LT, Cheng YC, Ke CY, and Lee YJ* (2017): Suppression of HSP27 restores retinal function and protects photoreceptors from apoptosis in a light-induced retinal degeneration animal model. Investigative Ophthalmology & Visual Science, 58(7): 3107–3117. (SCI) |
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Chien CC, Cai YJ, Tien LT, and Lee YJ* (2017): Subretinal transplantation of human amniotic membrane mesenchymal stem cell restores retinal function loss on light-induced retinopathy. Fu-Jen Journal of Medicine, 15(2): 59-78. |
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Cheng YP, Ke CY, Kuo CC, and Lee YJ* (2016): Effect of a complex lutein formula in an animal model for light-induced retinal degeneration. The Chinese Journal of Physiology, 59(4): 202-209. (SCI) |
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Cheng YC, Huang CJ, Lee YJ, Tien LT, Ku WC, Chien R, Lee FK, and Chieng CC* (2016). Knocking down of heat-shock protein 27 directs differentiation of functional glutamatergic neurons from placenta-derived multipotent cells. Scientific Reports, 6: 30314. (SCI) |
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Wang CY, Lin HC, Song YP, Hsu YT, Lin SY, Hsu PC, Lin CH, Hung CC, Hsu MC, Kuo YM, Lee YJ, Hsu CY, and Lee YH* (2015): PKC-dependent GAP43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses. Molecular and Cellular Biology, 35: 1712–1726. (SCI) |
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Lu YC, Wang CC, Lee CM, Hwang KS, Hua YM, Yuh YS, Chiu YL, Hsu WF, Chou YL, Huang SW, Lee YJ, and Fan HC* (2014): Reevaluating reference ranges of oxygen saturation for healthy full-term neonates using pulse oximetry. Pediatrics and Neonatology, 55(6): 459-465. (SCI) |
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Chen YI, Lee YJ, Wilkie DA, and Lin CT* (2014): Evaluation of potential topical and systemic neuroprotective agents for ocular hypertension-induced retinal ischemia-reperfusion injury. Veterinary Ophthalmology, 17(6): 432–442. (SCI, equal contribution to ChenYI, and LeeYJ) |
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Chien CC, Lim YT, and Lee YJ* (2014): Retinal transdifferentiation induced by NeuroD on retinal pigmented epithelial cells. Fu-Jen Journal of Medicine, 12: 151-160. |
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Wong CS, Lee YJ, Chiang YC, Fan LW, Ho IK, and Tien LT* (2014): Effect of prenatal methadone on reinstated behavioral sensitization induced by methamphetamine in adolescent rats. Behavioural Brain Research, 258: 160-165. (SCI, equal contribution to WongCS, LeeYJ and ChiangYC) |
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Lin PK, Ke CY, Khor CN, Cai YJ, and Lee YJ* (2013): Involvement of SDF1a and STAT3 in granulocyte colony-stimulating factor rescues optic ischemia-induced retinal function loss by mobilizing hematopoietic stem cells. Investigative Ophthalmology & Visual Science, 54: 1920-1930. (SCI) |
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Tsai MD, Chen PR, Tien LT, Cai YJ, and Lee YJ* (2013): Nuclear condensation and cell cycle arrest induced by telomerase siRNA in neuroblastoma cells. Journal of Neuro-Oncology, 111: 265-272. (SCI) |
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Wang KC, Lee YJ, Fan LW, Yang PP, Tao PL, Ho IK, and Tien LT* (2013): Mu-opioid receptor knockout mice are more sensitive to chlordiazepoxide-induced anxiolytic behavior. Brain Res Bulletin, 90: 137-141. (SCI) |
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Hu CK, Lee YJ, Colitz CM, Chang CJ, and Lin CT* (2012): The protective effects of Lycium barbarum and Chrysanthemum morifolum on diabetic retinopathies in rats. Veterinary Ophthalmology, 15(S2): 65-71. (SCI, equal contribution to HuCK and LeeYJ) |
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Hsiao WT, Tsai MD, Jow GM, Tien LT, and Lee YJ* (2012): Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. Molecular Vision, 18: 2033-2042. (SCI) |
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Chien CC, Lee YJ, Fan LW, Ho IK, and Tien LT* (2012): Naloxonazine, a specific mu-opioid receptor antagonist, attenuates the increment of locomotor activity induced by acute methamphetamine in mice. Toxicology Letters, 212: 61-65. (SCI, equal contribution to ChienCC and LeeYJ) |
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Yuan CY, Lee YJ*, and Wang Hsu GS* (2012): Aluminum overload increases oxidative stress in four functional brain areas of neonatal rats. Journal of Biomedical Science, 19: 51 (SCI) |
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Yuan CY, Wang Hsu GS*, and Lee YJ* (2011): Aluminum alters NMDA receptor 1A and 2A/B expression on neonatal hippocampal neurons in rats. Journal of Biomedical Science, 18: 81. (SCI) |
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Ku TH, Lee YJ, Wang SJ, Fan CH, and Tien LT* (2011): Effect of honokiol on activity of GAD65 and GAD67 in the cortex and hippocampus of mice. Phytomedicine, 18: 1126-1129. (SCI) |
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Hu CF, Fan HC, Lai CC, Lee YJ, and Chen SJ* (2011): Chorea: a rare presentation of moyamoya disease: a case report and literature review. Fu-Jen Journal of Medicine, 9: 107-112. |
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Cheng YC, Lee YJ, Huang CJ, Han CT, and Chien CC* (2010): Cytoskeleton proteomic changes in the process of placenta-derived multipotent cells (PDMCs) differentiated into neuron. Fu-Jen Journal of Medicine, 8: 1-8. (equal contribution to ChengYC and LeeYJ) |
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Cheng CK, Chan KC, and Lee YJ* (2009): Anti-proliferating effect of beauvericin on retinoblastoma. Fu-Jen Journal of Medicine, 7:161-169. |
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Fan HC, Lee YJ, and McNaughton PA* (2009): Pain, and why we need it. Journal of Medical Sciences. 29: 233-241. |
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Shyu WC, Li KW, Peng HF, Lin SZ, Liu RS, Wang HJ, Su CY, Lee YJ, and Li H* (2009): Induction of GAP-43 modulates neuroplasticity in PBSC (CD34+) implanted-Parkinson's model. Journal of Neuroscience Research, 87: 2020-2033. (SCI) |
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Cheng CK, Peng PH, Tien LT, Cai YJ, Chen CF, and Lee YJ* (2009): Bevacizumab is not toxic to retinal ganglion cells after repeated intravitreal injection. Retina, 29: 306-312. (SCI) |
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Peng PH, Huang HS, Lee YJ, Chen YS, and Ma MC* (2009): Novel role for the δ-opioid receptor in hypoxic preconditioning in rat retinas. Journal of Neurochemistry, 108: 741-754. (SCI) |
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Shyu WC, Chen CP, Lin SZ, Lee YJ, and Li H* (2007): Efficient tracking of non-iron-labeled mesenchymal stem cells with serial MRI in chronic stroke rats. Stroke, 38: 367-374. (SCI) |
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Chen CP, Lee YJ, Chiu ST, Shyu WC, Lee MY, Huang SP, and Li H* (2006): The application of stem cells in the treatment of ischemic diseases. Histology and Histopathology, 21: 1209-1216. (SCI) |
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Shyu WC, Lee YJ, Lin SZ, and Li H* (2006): Homing genes, cell therapy and stroke. Frontiers in Bioscience, 11: 889-907. (SCI) |
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Lin HI, Lee YJ, Chen BF, Tsai MC, Lu JL, Chou CJ, and Jow GM* (2005): Involvement of Bcl-2 family, cytochrome C and caspase 3 in induction of apoptosis by beauvericin in human on-small cell lung cancer cells. Cancer Letters, 230:248-259. (SCI) |
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Shyu KG, Jow GM, Lee YJ and Wang SJ* (2005): PP2 inhibits glutamate release from nerve endings by affecting vesicle mobilization. Neuroreport, 16:1969-1972 (SCI) |
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Shyu WC, Chen CP, Saeki K, Kubosaki A, Matsumoto Y, Onodera T, Ding DC, Chiang MF, Lee YJ, Lin SZ and Li H* (2005): Hypoclycemia enhances the expression of prion protein and heat shock protein 70 in a mouse neuroblastoma cell line. Journal of Neuroscience Research, 80: 887-894. (SCI) |
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Shyu WC, Lin SZ, Chiang MF, Pang CY, Chen SY, Hsin YL, Thajeb P, Lee YJ and Li H* (2005): Early-onset Parkinson’s disease in a Chinese population: 99mTc-TRODAT-1 SPECT, Parkin gene analysis and clinical study. Parkinsonism & Related Disorders, 11: 173-180. (SCI) |
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Lee YJ, Wang D., and Jow GM* (2004): Confocal Microscopy in Biomedical and Clinical applications. Fu-Jen Journal of Medicine, 2:263-271. |
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Tsai LH*, Lee YJ, and Wu JY (2004): Role of N-methyl-D-aspartate receptors in gastric mucosal blood flow induced by histamine. Journal of Neuroscience Research, 77: 730-738. (SCI) |
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Yang TT, Hung CF, Lee YJ, Su MJ, and Wang SJ* (2004): Morphine inhibits glutamate exocytosis from rat cerebral cortex nerve terminals (synaptosomes) by reducing Ca2+ influx. Synapse, 51: 83-90. (SCI) |
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Huang SP, Lin PK, Liu JH, Khor CN, and Lee YJ* (2004): Intraocular Gene Transfer of Ciliary Neurotrophic Factor Rescues Photoreceptor Degeneration in RCS rats. Journal of Biomedical Science, 11: 37-48. (SCI) |
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Lee YJ, Zachrisson O, Tonge DA, and McNaughton PA* (2002): Upregulation of bradykinin B2 receptor mRNA and protein expression by neurotrophic factors and nerve injury in mouse sensory neurons. Molecular Cellular Neuroscience, 19: 186-200. (SCI) |
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Tsai LH* and Lee YJ (2001): NMDA inhibits oxotremorine-induced acid secretion via the NO-dependent cyclic GMP system in rat stomach. Chinese Journal of Physiology, 44: 193-198. (SCI) |
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Vellani V, Mapplebeck S, Moriondo A, Davis LB, Bonnington JK, Lee YJ, Zachrisson O, Tonge DA, and McNaughton PA* (2001): Sensitization in nociceptors. Journal of Physiology, 528: 536P. (SCI) |
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Lee YJ, Zachrisson O., Tonge D. A., and McNaughton P. A.* (2000): Effects of media conditioned by lesioned tissue on bradykinin B2 receptor expression in adult mouse sensory neurons. Journal of Physiology, 523: 91P (SCI) |
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Lee YJ, Zachrisson O., Tonge D. A., and McNaughton P. A.* (1999): Upregulation of bradykinin B2 receptor gene expression in mouse sensory neurons by NGF and nerve injury. Journal of Physiology, 518: 513P (SCI) |
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Tsai LH*, Lee YJ, and Wu JY (1999): Effect of excitatory amino acid neurotransmitters on acid secretion in the rat stomach. Journal of Biomedical Science, 6: 36-44. (SCI) |
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Conference Paper
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Lee YJ*, Chen YC, Hsieh HJ, Ke CY, Tien N, and Lin PK (2019): High-level of homocysteine alters cell viability of endothelial cell and Müller cell. The 9th Federation of the Asian and Oceanian Physiological Societies Congress, 2P-493. Kobe, Japan. March, 2019. |
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Lee YJ*, Huang CJ, Tien LT, Ke CY, Ku WC, Cheng YC, and Chien CC (2018): Suppression of S100A16 and HSP27 restores retinal function and reverses retinal cell apoptosis caused by a long‐term light exposure. The 11th FENS Forum of Neuroscience 2018, F18‐0568. Berlin, Germany. July, 2018. |
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Tien LT*, Lee YJ, and Fan LW (2018): Intranasal IGF-1 protects against neonatal lipopolysaccharide-induced neurobehavioral deficits and neuronal inflammation in juvenile rats. The 11th FENS Forum of Neuroscience 2018, F18-2880. Germany. July, 2018. |
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Chien CC*, Cheng YC, Huang CJ, Tien L, and Lee YJ (2017): Knocking down of heat-shock protein 27 and one of the members of S100 superfamily induces differentiation of functional glutamatergic neurons and astrocytes from placenta-derived multipotent cells. Society for Neuroscience Annual Meeting 2017, Nanosymposium 10.05. Washington DC, USA. November, 2017. |
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Tien LT*, Lee YJ, Chien CC, Lu S, and Fan LW (2017): Intranasal IGF-1 protects against neonatal lipopolysaccharide-induced neuroal inflammation in the brain of juvenile rats. Society for Neuroscience Annual Meeting 2017, 303.07. Washington DC, USA. November, 2017. |
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Lee YJ*, Ke CY, and Lin PK (2016): Hyperhomocysteinemia caused chorioretinal vasculopathy in an animal model. European Association for Vision and Eye Research (EVER) 2016 Congress, T085. Nice, France. Ocotber, 2016. |
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Lee YJ*, Ke CY, and Lin PK (2016): High level of homocysteine causes retinal cell loss and choroid thickening in a rat model. The 10th FENS Forum of Neuroscience 2016, FENS-1736. Copenhagen, Denmark. July, 2016. |
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Lin PK, Chiu CC, Ke CY, and Lee YJ (2016): Effects of anti-VEGFs on choroidal vessel outgrowth by an hcy-evoked choroidal capillary sprouting explant model. The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) 2016, 4521-B0272. Seattle, Washington, USA. May, 2016. |
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Tien LT*, Lee YJ, Lee JA, and Fan LW (2015): Neonatal lipopolysaccharide-induced long-lasting learning impairment and hippocampal injury was attenuated by IL-1 receptor antagonist in adult rats. Society for Neuroscience Annual Meeting 2015, 74.14. Chicago, Illinois, USA. October, 2015. |
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Lee YJ*, Huang CJ, Cheng YC, Tien LT, Ke CY, and Chien CC (2014): HSP27 alters retinal cell existence in a light-induced retinal degenerative model. Society for Neuroscience Annual Meeting 2014, 433.16. Washington DC, USA. November, 2014. |
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Tien LT*, Lee YJ, and Fan LW (2014): Systemic neonatal lipopolysaccharide-induced brain injury can be ameliorated by melatonin. Society for Neuroscience Annual Meeting 2014, 528.15. Washington DC, USA. November, 2014. |
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Tien LT*, Wong CS, Lee YJ, Chiang YC, Fan LW, and Ho IK (2014): Effect of prenatal methadone on reinstated behavioral sensitization induced by methamphetamine in adolescent rats. The 53rd Annual Meeting of the Society of Toxicology. P369. Phoenix, Arizona, USA. March, 2014. |
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Huang TC, Li YC, Lee YJ, Tien LT, and Lee JA* (2014): Ameliorative effects of metformin on aristolochic acid-induced renal toxicity in mice due to its ability to control methylglyoxal and N-(carboxymethyl)lysine accumulation. The 53rd Annual Meeting of the Society of Toxicology. P2060. Phoenix, Arizona, USA. March, 2014. |
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Chiu CJ, Jow GM, and Lee YJ* (2014): Antioxidant effect of brassica oleracea sprout extract on ARPE-19 cells. The 29th Joint Annual Conference of Biomedical Science. P495. March, 2014 |
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Lee YJ*, Tsai MD, Cai YJ, and Tien LT (2013): Possible pathways for human telomerase RNA interference inhibits cell proliferation of retinoblastoma cells. Society for Neuroscience Annual Meeting 2013, 446.06. San Diego, California, USA. November, 2013. |
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Chen, YC, Tsai MD, Jow GM, Tien LT, and Lee YJ* (2012): Involvement of p53, smac, and caspase pathways for anti-proliferative effect of 2-methoxyestradiol on human neuroblastoma cells. Society for Neuroscience Annual Meeting 2012, 661.07. October, 2012. |
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Cai YJ, and Lee YJ* (2012): Applications of human amniotic membrane mesenchymal stem cell on light-induced retinopathy in rats. The 27th Joint Annual Conference of Biomedical Science. P148. March, 2012. |
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Tsai MD, Chen PR, and Lee YJ* (2011): Anti-proliferative effect of telomerase RNA interference on neuroblastoma cell. 13th Asian Australasian Congress of Neurological Surgeons. Taipei, TAIWAN. December, 2011. |
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Lee YJ*, Hsiao WT, Tsai MD, Jow GM, and Tien LT (2011): Anti-proliferating effect of gossypol on human retinoblastoma cells. Society for Neuroscience Annual Meeting 2011, 678.06. Washington DC, USA. November, 2011. |
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Tien LT*, Lee YJ, and Ho IK (2011): Naloxonazine, specific mu-opioid receptor antagonist, inhibits locomotor activity induced by methamphetamine in mice. Society for Neuroscience Annual Meeting 2011, 81.10. Washington DC, USA. November, 2011. |
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Chen YA, Jow GM, and Lee YJ* (2011): Anti-proliferative effect of 2-methoxyestradiol on retinoblastoma cells. The 7th FAOPS Congress, P-S11. Taipei, TAIWAN. September, 2011. |
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Lee YJ*, Lim YT, and Tien LT (2010): Intraocular transplantation of umbilical cord mesenchymal stem cells rescues retinal functional loss in lightinduced retinopathy. Experimental Biology 2010 Annual Meeting, LB511. Anaheim, California, USA. April 2010. |
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Tien LT*, and Lee YJ (2010): Change in down-stream signaling of striatal dopaminergic transmission in methamphetamine-sensitized mice. Experimental Biology 2010 Annual Meeting, LB456. Anaheim, California, USA. April 2010. |
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Chang SC, Lee YJ, Yeh YP, Lo PW, Ho IK, and Tien LT* (2010): Change in down-stream signaling of striatal dopaminergic transmission after administration of methamphetamine in mice. The 25th Joint Annual Conference of Biomedical Science, P116. March 2010. |
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Hsiao WT, Jow GM, and Lee YJ* (2010): The anti-proliferating effect of gossypol on human retinoblastoma cell ine. The 25th Joint Annual Conference of Biomedical Science, P649. March 2010. |
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Cai YJ, Tien LT, Tsai MD, and Lee YJ* (2010): Inhibition of cell proliferation of retinoblastoma by telomerase RNA interference. The 25th Joint Annual Conference of Biomedical Science, P860. March 2010. |
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Lim YT, Tien LT, Lin CT and Lee YJ* (2009): Applications of Wharton's jelly cell therapy on light-induced retinopathy in rat model. International Symposium of Stem Cell and Bioengineering 2009, TSSCR, Tainan, TAIWAN. May 2009. |
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Lee YJ*, Ke CY, Lin CC, and Chen CP (2007): Transplantation of mesenchymal stem cell reduces retinal functional loss after retinal ischemia. Society for Neuroscience 2007: 899.10. San Diego, California, USA. November, 2007. |
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