學歷
學校 系所 學位
國立成功大學 基礎醫學研究所 博士
經歷
期間 單位 部門 職稱
輔仁大學 學術特聘教授
輔仁大學 研發長
輔仁大學 基礎醫學研究所 所長
英國倫敦大學 博士後研究
國立成功大學 博士後研究
專長
電生理學
神經科學
神經藥理學
學術著作
期刊論文
期間 內容
期刊論文(2018至今)
1. Lin TK, Yeh KC, Pai MS, Hsieh PW, Wang SJ*. (2023 Dec 17) Ursolic acid inhibits the synaptic release of glutamate and prevents glutamate excitotoxicity in rats. Eur J Pharmacol. 963:176280.
2. Pai MS, Wang KC, Yeh KC, Wang SJ*. (2023 Dec) Stabilization of mitochondrial function by chlorogenic acid protects against kainic acid-induced seizures and neuronal cell death in rats. Eur J Pharmacol. 961:176197.
3. Lu CW, Lin TY, Hsieh PW, Chiu KM, Lee MY, Wang SJ*. (2023 May) Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Neurochem Int. 167:105537.
4. Hsu SK, Lu CW, Chiu KM, Lee MY, Lin TY*, Wang SJ*. (2023 Jul) Mangiferin depresses vesicular glutamate release in synaptosomes from the rat cerebral cortex by decreasing synapsin I phosphorylation. Eur J Pharmacol. 950:175772.
5. Chiu KM, Lee MY, Lu CW*, Lin TY*, Wang SJ*. (2023 Jan) Plantainoside D reduces depolarization-evoked glutamate release from rat cerebral cortical synaptosomes. Molecules, 28, 1313.
6. Lu CW, Wu CC, Chiu KM, Lee MY, Lin TY*, Wang SJ*. (2022 Nov) Inhibition of synaptic glutamate exocytosis and prevention of glutamate neurotoxicity by eupatilin from Artemisia argyi in the rat cortex. Int J Mol Sci. 23(21):13406.
7. Chang A, Chang Y, Wang SJ*. (2022 Oct) Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation. Food Funct.13(20):10401-10414.
8. Lu CW, Yeh KC, Chiu KM, Lee MY, Lin TY*, Wang SJ*. (2022 Aug) The effect of isosaponarin derived from Wasabi leaves on glutamate release in rat synaptosomes and its underlying mechanism. Int J Mol Sci 23(15):8752.
9. Chiu KM, Lin TY, Lee MY, Lu CW, Wang SJ*. (2022 Jul) Lappaconitine inhibits glutamate release from rat cerebrocortical nerve terminals by suppressing Ca2+ influx and protein kinase A cascade. Neurotoxicology 91:218-227.
10. Hsieh TY, Chang Y, Wang SJ*. (2022 Apr) Piperine provides neuroprotection against kainic acid-induced neurotoxicity via maintaining NGF signalling pathway. Molecules. 27(9):2638.
11. Jean WH, Huang CT, Hsu JH, Chiu KM, Lee MY, Shieh JS, Lin TY*, Wang SJ*. (2022 May) Anticonvulsive and neuroprotective effects of eupafolin in rats are associated with the inhibition of glutamate overexcitation and upregulation of the wnt/β-catenin signaling pathway. ACS Chem Neurosci 13(10):1594-1603.
12. Lin TY, Hung CY, Chiu KM, Lee MY, Lu CW*, Wang SJ*. (2022 Apr) Neferine, an alkaloid from lotus seed embryos, exerts antiseizure and neuroprotective effects in a kainic acid-induced seizure model in rats. Int J Mol Sci 23(8):4130.
13. Yeh KC, Hung CF, Lee HL, Hsieh TY, Wang SJ*. (2022 Mar) Soybean meal extract preserves memory ability by increasing presynaptic function and modulating gut microbiota in rats. Mol Neurobiol 59(3):1649-1664.
14. Lu CW, Lin CJ, Hsieh PW, Chiu KM, Lee MY, Lin TY*, Wang SJ*. (2022 Feb) An anthranilate derivative inhibits glutamate release and glutamate excitotoxicity in rats. Int J Mol Sci 23(5):2641.
15. Lin TK, Hung CF, Weng JR, Hsieh TY, Wang SJ*. (2022 Feb) Kaempferol 3-rhamnoside on glutamate release from rat cerebrocortical nerve terminals involves P/Q-Type Ca2+ channel and Ca2+/calmodulin-dependent protein kinase II-dependent pathway suppression. Molecules 27(4):1342.
16. Lin TY, Chen IY, Lee MY, Lu CW, Chiu KM*, Wang SJ*. (2022 Jan) Inhibition of glutamate release from rat cortical nerve terminals by dehydrocorydaline, an alkaloid from Corydalis yanhusuo. Molecules 27(3):960.
17. Lu CW, Huang YC, Chiu KM, Lee MY, Lin TY*, Wang SJ*.
18. Hung YC, Kuo YH, Hsieh PW, Hsieh TY, Kuo JR, Wang SJ*. (2021 Oct) Chlorogenic acid decreases glutamate release from rat cortical nerve terminals by P/Q-Type Ca2+ channel suppression: a possible neuroprotective mechanism. Int J Mol Sci 22(21):11447.
19. Lin TY, Lu CW, Hsieh PW, Chiu KM, Lee MY, Wang SJ*. (2021 Oct) Natural product isoliquiritigenin activates GABAB receptors to decrease voltage-gate Ca2+ channels and glutamate release in rat cerebrocortical nerve terminals. Biomolecules 18;11(10):1537.
20. Chang A, Hung CF, Hsieh PW, Ko HH, Wang SJ*. (2021 Nov) Eupafolin suppresses P/Q-Type Ca2+ channels to inhibit Ca2+/calmodulin-dependent protein kinase II and glutamate release at rat cerebrocortical nerve terminals. Biomol Ther (Seoul). 29(6):630-636.
21. Wang CC, Hsieh PW, Kuo JR, Wang SJ*. (2021 Jul) Rosmarinic acid, a bioactive phenolic compound, inhibits glutamate release from rat cerebrocortical synaptosomes through GABAA receptor activation. Biomolecules 11(7):1029.
22. Lu CW, Lin TY, Huang SK, Chiu KM, Lee MY, Huang JH, Wang SJ*. (2021 Jul) Inhibition of glutamatergic transmission and neuronal excitability by oxycodone in the rat hippocampal CA3 neurons. Can J Physiol Pharmacol 99(7):737-743
23.Chiu KM, Lin TY, Lee MY, Lu CW, Wang MJ, Wang SJ*. (2021 May) Typhaneoside suppresses glutamate release through inhibition of voltage-dependent calcium entry in rat cerebrocortical nerve terminals. Chem Res Toxicol 34(5):1286-1295
24.Wang CC, Kuo JR, Wang SJ*. (2021 Mar) Fingolimod inhibits glutamate release through activation of S1P1 receptors and the G protein βγ subunit-dependent pathway in rat cerebrocortical nerve terminals. Neuropharmacology 185:108451.
25.Chang Y, Hung CF, Ko HH, Wang SJ*. (2021 Mar) Albanin A, derived from the root bark of Morus alba L., depresses glutamate release in the rat cerebrocortical nerve terminals via Ca2+/calmodulin/adenylate cyclase 1 suppression. J Med Food 24(3):209-217.
26.Lu CW, Lin TY, Pan TL, Wang PW, Chiu KM, Lee MY, Wang SJ*. (2021 Mar) Asiatic acid prevents cognitive deficits by inhibiting calpain activation and preserving synaptic and mitochondrial function in rats with kainic acid-induced seizure. Biomedicines 2021, 9(3), 284
27.Hsu SK, Hung CF, Yang HC, Weng JR, Wang SJ*. (2020 Nov) TCD, a triterpenoid isolated from wild bitter gourd, reduces synaptosomal release of glutamate and protects against kainic acid-induced neuronal death. Food Funct 11(11):9858-9867.
28.Lu CW, Lin TY, Chiu KM, Lee MY, Huang JH, Wang SJ*. (2020 Nov) Silymarin Inhibits Glutamate Release and Prevents against Kainic Acid-Induced Excitotoxic Injury in Rats. Biomedicines 8(11): E486.
29.Yeh KC, Hung CF, Lin YF, Chang C, Pai MS, Wang SJ*. (2020 Sep) Neferine, a bisbenzylisoquinoline alkaloid of Nelumbo nucifera, inhibits glutamate release in rat cerebrocortical nerve terminals through 5-HT1A receptors. Eur J Pharmacol 889:173589.
30.Lu CW, Lin TY, Yang HC, Hung CF, Weng JR, Chang C, Wang SJ*. (2020, Nov) [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, inhibits glutamate release in rat cerebrocortical nerve terminals by suppressing the P/Q-type Ca2+ channels and Ca2+/calmodulin/protein kinase A pathway. Neurochem Int 140:104845.
31.Lu CW, Huang S K, Lin TY, Wang SJ*. (2020, Sep) Tapentadol suppresses glutamatergic transmission and neuronal firing in rat hippocampal CA3 pyramidal neurons. Pharmacology, 105(7-8):445-453.
32.Wang CC, Ho YH, Hung CF, Kuo JR, Wang SJ*. (2020) Xanthohumol, an active constituent from hope, affords protection against kainic acid-induced excitotoxicity in rats. Neurochem Int 133:104629.
33.Lu CW, Lin TY, Wang SJ*. (2020) 11-Keto-β-boswellic acid attenuates glutamate release and kainic acid-induced excitotoxicity in the rat hippocampus. Planta Med 86(6):434-441.
34.Hsieh TY, Chang Y, Wang SJ*. (2019) Piperine-mediated suppression of voltage-dependent Ca2+ influx and glutamate release in rat hippocampal nerve terminals involves 5HT1A receptors and G protein βγ activation. Food Funct 10:2720-2728.
35.Lu CW, Lin TY, Wang SJ*, Huang SK. (2019) Asiatic acid, an active substance of Centella asiatica, presynaptically depresses glutamate release in the rat hippocampus. European Journal of Pharmacology 865:172781.
36.Su IC, Hung CF, Lin CN, Huang SK, Wang SJ*. (2019) Cycloheterophyllin inhibits the release of glutamate from nerve terminals of the rat hippocampus. Chem Res Toxicol 32:1591-1598.
37.Chiu KM, Lin TY, Lee MY, Lu CW, Wang MJ, Wang SJ*. (2019) Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling. Neurochem. Int. 129: 104493.
38.Lu CW, Hung CF, Lin TY, Hsieh TY, Wang SJ*. (2019) Allicin Inhibits Glutamate Release from Rat Cerebral Cortex Nerve Terminals Through Suppressing Ca2+ Influx and Protein Kinase C Activity. J Med Food 22:696-702.
39.Chang Y, Hsieh HL, Huang SK, Wang SJ*. (2019) Neurosteroid allopregnanolone inhibits glutamate release from rat cerebrocortical nerve terminals. Synapse 73: 1-11.
40.Lu CW, Hsieh HL, Lin TY, Hsie TY, Huang SK, Wang SJ*. (2018) Echinacoside, an active constituent of Cistanche Herba, exerts a neuroprotective effect in a kainic acid rat model by inhibiting inflammatory processes and activating the Akt/ GSK3 Pathway. Biol. Pharm. Bull. 41:1685-1693.
41.Chiu KM, Wu CC, Wang MJ, Lee MY, Wang SJ*. (2018) Ropivacaine protects against memory impairment and hippocampal damage in a rat neurodegeneration model. Pharmacology 102:307-315.
42.Lu CW, Lin TY, Huang SK, Wang SJ*. (2018) 5-HT1B receptor agonist CGS12066 presynaptically inhibits glutamate release in rat hippocampus. Progress in Neuropsychopharmacology & Biological Psychiatry 86:122-130.
43.Chang Y, Lu CW, Chen YC, Lin TY, Huang SK, Wang SJ*. (2018) Astaxanthin protects against kainic acid-induced seizures and pathological consequences. Neurochemistry International 116: 85-94.
44.Wang CC, Kuo JR, Huang SK, Wang SJ*. (2018) Metabotropic glutamate 7 receptor agonist AMN082 inhibits glutamate release in rat cerebral cortex nerve terminal. European Journal of Pharmacology 823:11-18.
45.Lu CW, Hung CF, Jean WH, Lin TY, Huang SK, Wang SJ*. (2018) Lycopene depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebrocortical nerve terminals. CJPP. 96(5):479-484.
其他教學經驗
其他教學經驗
期間 內容
醫學系/PBL小班導師及藥理學大堂授課
護理系/藥理學
呼吸治療系/藥理學
臨心系/藥理學