學歷
學校 系所 學位
台大醫學院 藥理學研究所 博士、碩士
高雄醫學院 藥學系 學士
經歷
期間 單位 部門 職稱
輔仁大學 學術特聘教授
哈佛大學暨波士頓兒童醫院 訪問學者
輔仁大學 研發處 研發長
輔仁大學 醫學院 行政副院長
輔仁大學 長期照護碩士學位學程 主任
輔仁大學 產學育成中心 主任
輔仁大學 海量資料研究中心 主任
輔仁大學 研究管理組 組長
輔仁大學 樂齡大學 主任
輔仁大學 醫學系 副教授、助理教授
高雄醫學大學 藥學系 合聘教授
高雄醫學大學 香粧品系 合聘教授
中華天然藥物學會 第十屆理事
國際跨專業長期照顧協會 理事長
台北市高雄醫學大學 藥學系校友會 理事長
高雄醫學大學 藥學院校友會 會長
國際醫療翻譯協會 副理事長
國防醫學院 藥研所 博士後研究
專長
Skinceuticals
Cardiovascular pharmacology
Natural products
學術著作
期刊論文
期間 內容
Publications from 2017 (學術期刊發表)
1.Wang CC, Hsiao CY, Hsu YJ, Ko HH, Chang DC, Hung CF*. Anti-Inflammatory Effects of Cycloheterophyllin on Dinitrochlorobenzene-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice. Molecules 2022, 27, 2610.
2. Ko WC, Wang SJ, Hsiao CY, Hung CT, Hsu YJ, Chang DC, Hung CF*. Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications. Molecules 2022,27, 155.
3. Lin TK, Hung CF, Weng JR, Hsieh TY, Wang SJ. Kaempferol 3-Rhamnoside on Glutamate Release from Rat Cerebrocortical Nerve Terminals Involves P/Q-Type Ca2+ Channel and Ca2+/Calmodulin-Dependent Protein Kinase II-Dependent Pathway Suppression. Molecules 2022 Feb 16;27(4):1342.
4. Huang CC, Liu CY, Huang CJ, Hsu YC, Lien HH, Wong JU, Tai FC, Ku WH, Hung CF, Lin JT, Huang CS, Chiang HS. Deciphering Genetic Alterations of Taiwanese Patients with Pancreatic Adenocarcinoma through Targeted Sequencing. Int J Mol Sci. 2022 Jan 29;23(3):1579.
5. Yeh KC, Hung CF, Lee HL, Hsieh TY, Wang SJ. Soybean Meal Extract Preserves Memory Ability by Increasing Presynaptic Function and Modulating Gut Microbiota in Rats. Mol Neurobiol 2022 Mar;59(3):1649-1664.
6. Lu PH, Wang JY, Chiu LY, Huang YT, Hung CF, Wu NL. Spleen tyrosine kinase regulates keratinocyte inflammasome activation and skin inflammation induced by UVB irradiation. Free Radic Biol Med. 2022 Feb 20;180:121-133.
7. Liang IC, Ko WC, Hsu YJ, Lin YR, Chang YH, Zong XH, Lai PC, Chang DC, Hung CF*, The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration. Int. J. Mol. Sci. 2021, 22(21), 12049
8. Chiu KM, Hung YL, Wang SJ, Tsai YJ, Wu NL, Liang CW, Chang DC, Hung CF*, Anti-allergic and anti-inflammatory effects of neferine on RBL-2H3 cells. International Journal of Molecular Sciences 2021, 22, 10994
9. Chang HH, Hung CF, Chen IC, Wu PC, Liu LW, Fang CC. Long-Term Clinical Outcomes of New-Generation Drug-Eluting Stents in Coronary Artery Disease: A Real-World Observational Study. Acta Cardiol Sin. 2021 37, 484-495.
10. Yang CC, Hung YL, Ko WC, Tsai YJ, Chang JF, Liang CW, Chang DC, Hung CF*, Effect of neferine on DNCB-induced atopic dermatitis in HaCaT Cells and BALB/c mice. International Journal of Molecular Sciences 2021, 22, 8237
11. Chang CJ, Hung YL, Chen TC, Li HJ, Lo YH, Wu NY, Chang DC, Hung CF*, Anti-proliferative and anti-migratory activities of hispidulin on human melanoma A2058 Cells. Biomolecules 2021,11, 1039
12. Yang CC, Hung YL, Li HJ, Lin YF, Wang SJ, Chang DC, Pu CM, Hung CF*, Quercetin inhibits histamine-induced calcium influx in human keratinocyte via histamine H4 receptors. International Immunopharmacology 2021, 96, 107620
13. Chang HH, Ko HH, Lu TM, Lin JY, Chang DC, Chu TW*, Hung CF*, Inhibition of UVA Damage on Human Skin Dermis Fibroblasts by the Isoflavonoid Intermediate Deoxybenzoin-3A. Chem Res Toxicol 2021, 34(4),1133-1139
14. Chang HH, Hung CF, Chen IC, Wu PC, Liu LW, Fang CC, Long-Term Clinical Outcomes of New-Generation Drug-Eluting Stents in Coronary Artery Disease: A Real-World Observational Study. Acta Cardiol Sin 2021, 37, 484-495.
15. Liang IC, Hsiang Y, Chang YH, Martínez AH, Hung CF*, Irisclaw intraocular lens: Anterior chamber or retropupillary implantation? A systematic review and meta-analysis. Medicina 2021, 57(8), 785
16. Chang A, Hung CF, Hsieh PW, Ko HH, Wang SJ. Eupafolin suppresses P/Q-type Ca2+ channels to inhibit Ca2+/ calmodulin-dependent protein kinase II and glutamate release at rat cerebrocortical nerve terminals. Biomol Ther (Seoul) 2021 Sep 3. doi: 10.4062/biomolther.2021.046.
17. Liao, Z. Y.; Liou, J. Y.; Lin, S. C.; Hung, H. F.; Chang, C. M.; Chen, L. C.; Chua, S. K.; Lo, H. M.; Hung, C. F.*, Successful bailout stenting strategy against rare spontaneous retrograde dissection of partially absorbed magnesium-based resorbable scaffold: A case report. World J Clin Cases 2021, 9 (5), 1148-1155.
18. Chiu, L. Y.; Wu, N. L.; Hung, C. F.; Bai, P.; Dai, Y. S.; Lin, W. W., PARP-1 involves in UVB-induced inflammatory response in keratinocytes and skin injury via regulation of ROS-dependent EGFR transactivation and p38 signaling. FASEB J 2021, 35 (3), e21393.
19. Lin, M.-H.#; Hung, C.-F#; Sung, H.-C.; Yang, S.-C.; Yu, H.-P.; Fang, J.-Y., The Bioactivities of Resveratrol and Its Naturally Occurring Derivatives on Skin. Journal of Food and Drug Analysis 2021, 29 (1), 15-38.
20. Chang, Y.; Hung, C. F.; Ko, H. H.; Wang, S. J., Albanin A, Derived from the Root Bark of Morus alba L., Depresses Glutamate Release in the Rat Cerebrocortical Nerve Terminals via Ca2+/Calmodulin/Adenylate Cyclase 1 Suppression. Journal of Medicinal Food 2021, 24 (3), 209-217.
21. Lin, Y.-C.; Fang, Y.-P.; Hung, C.-F.; Yu, H.-P.; Alalaiwe, A.; Wu, Z.-Y.; Fang, J.-Y., Multifunctional TiO2/SBA-15 mesoporous silica hybrids loaded with organic sunscreens for skin application: the role in photoprotection and pollutant adsorption with reduced sunscreen permeation. Colloids and Surfaces B: Biointerfaces 2021, 111658.
22. Yeh, K. C.; Hung, C. F.; Lin, Y. F.; Chang, C.; Pai, M. S.; Wang, S. J., Neferine, a bisbenzylisoquinoline alkaloid of Nelumbo nucifera, inhibits glutamate release in rat cerebrocortical nerve terminals through 5-HT(1A) receptors. Eur J Pharmacol 2020, 889, 173589.
23. Wang, J. Y.; Lu, P. H.; Lin, W. W.; Wei, Y. H.; Chiu, L. Y.; Chern, S. R.; Hung, C. F.; Wu, N. L., Galectin-3 regulates UVB-induced inflammation in skin. J Dermatol Sci 2020, 98 (2), 119-127.
24. Wang, C. C.; Ho, Y. H.; Hung, C. F.; Kuo, J. R.; Wang, S. J., Xanthohumol, an active constituent from hope, affords protection against kainic acid-induced excitotoxicity in rats. Neurochem Int 2020, 133, 104629.
25. Lu, C. W.; Lin, T. Y.; Yang, H. C.; Hung, C. F.; Weng, J. R.; Chang, C.; Wang, S. J., [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, inhibits glutamate release in rat cerebrocortical nerve terminals by suppressing the P/Q-type Ca(2+) channels and Ca(2+)/calmodulin/protein kinase A pathway. Neurochem Int 2020, 140, 104845.
26. Liao, Z. Y.; Liang, I. C.; Li, H. J.; Wu, C. C.; Lo, H. M.; Chang, D. C.; Hung, C. F.*, Chrysin Inhibits High Glucose-Induced Migration on Chorioretinal Endothelial Cells via VEGF and VEGFR Down-Regulation. Int J Mol Sci 2020, 21 (15).
27. Li, H. J.; Wu, N. L.; Pu, C. M.; Hsiao, C. Y.; Chang, D. C.; Hung, C. F.*, Chrysin alleviates imiquimod-induced psoriasis-like skin inflammation and reduces the release of CCL20 and antimicrobial peptides. Sci Rep 2020, 10 (1), 2932.
28. Hsu SK, Hung CF, Yang HC, Weng JR, Wang SJ: TCD, a triterpenoid isolated from wild bitter gourd, reduces synaptosomal release of glutamate and protects against kainic acid-induced neuronal death. Food Funct 2020, 11(11):9858-9867.
29. Chu, T.; Wu, N. L.; Hsiao, C. Y.; Li, H. J.; Lin, T. Y.; Ku, C. H.; Hung, C. F.*, An isoflavone extract from soybean cake suppresses 2,4-dinitrochlorobenzene-induced contact dermatitis. J Ethnopharmacol 2020, 263, 113037.
30. Chen, C. Y.; Hu, J. M.; Shen, C. J.; Chou, Y. C.; Tian, Y. F.; Chen, Y. C.; You, S. L.; Hung, C. F.; Lin, T. C.; Hsiao, C. W.; Lin, C. Y.; Sun, C. A., Increased incidence of colorectal cancer with obstructive sleep apnea: a nationwide population-based cohort study. Sleep Med 2020, 66, 15-20.
31. Chang, J. F.; Hsieh, C. Y.; Lu, K. C.; Chen, Y. W.; Liang, S. S.; Lin, C. C.; Hung, C. F.; Liou, J. C.; Wu, M. S., Therapeutic Targeting of Aristolochic Acid Induced Uremic Toxin Retention, SMAD 2/3 and JNK/ERK Pathways in Tubulointerstitial Fibrosis: Nephroprotective Role of Propolis in Chronic Kidney Disease. Toxins (Basel) 2020, 12 (6).
32. Chang, J. F.; Hsieh, C. Y.; Liou, J. C.; Liu, S. H.; Hung, C. F.; Lu, K. C.; Lin, C. C.; Wu, C. C.; Ka, S. M.; Wen, L. L.; Wu, M. S.; Zheng, C. M.; Ko, W. C., Scavenging Intracellular ROS Attenuates p-Cresyl Sulfate-Triggered Osteogenesis through MAPK Signaling Pathway and NF-κB Activation in Human Arterial Smooth Muscle Cells. Toxins (Basel) 2020, 12 (8).
33. Wu, W. T.; Tsai, C. T.; Chou, Y. C.; Ku, P. M.; Chen, Y. C.; You, S. L.; Hung, C. F.; Sun, C. A., Cardiovascular Outcomes Associated with Clinical Use of Citalopram and Omeprazole: A Nationwide Population-Based Cohort Study. J Am Heart Assoc 2019, 8 (20), e011607.
34. Wang, H. E.; Liao, Y. C.; Hu, J. M.; Wu, W. C.; Chou, W. Y.; Chen, Y. C.; Chou, Y. C.; Hung, C. F.; Tian, Y. F.; You, S. L.; Sun, C. A., Correlation between kidney transplantation and colorectal cancer in hemodialysis patients: A nationwide, retrospective, population-based cohort study. BMC Cancer 2019, 19 (1), 1120.
35. Su, I. C.; Hung, C. F.; Lin, C. N.; Huang, S. K.; Wang, S. J., Cycloheterophyllin Inhibits the Release of Glutamate from Nerve Terminals of the Rat Hippocampus. Chem Res Toxicol 2019, 32 (8), 1591-1598.
36. Lu, C. W.; Hung, C. F.; Lin, T. Y.; Hsieh, T. Y.; Wang, S. J., Allicin Inhibits Glutamate Release from Rat Cerebral Cortex Nerve Terminals Through Suppressing Ca(2+) Influx and Protein Kinase C Activity. J Med Food 2019, 22 (7), 696-702.
37. Lin, M. H.; Hung, C. F.; Hsu, C. Y.; Lin, Z. C.; Fang, J. Y., Prodrugs in combination with nanocarriers as a strategy for promoting antitumoral efficiency. Future Med Chem 2019, 11 (16), 2131-2150.
38. Chan, C. M.; Hsiao, C. Y.; Li, H. J.; Fang, J. Y.; Chang, D. C.; Hung, C. F.*, The Inhibitory Effects of Gold Nanoparticles on VEGF-A-Induced Cell Migration in Choroid-Retina Endothelial Cells. Int J Mol Sci 2019, 21 (1).
39. Zheng, C. M.; Wu, C. C.; Hung, C. F.; Liao, M. T.; Shyu, J. F.; Hsu, Y. H.; Lu, C. L.; Wang, Y. H.; Zheng, J. Q.; Chang, T. J.; Lin, Y. F.; Lu, K. C., Cholecalciferol Additively Reduces Serum Parathyroid Hormone Levels in Severe Secondary Hyperparathyroidism Treated with Calcitriol and Cinacalcet among Hemodialysis Patients. Nutrients 2018, 10 (2).
40. Lu, C. W.; Hung, C. F.; Jean, W. H.; Lin, T. Y.; Huang, S. K.; Wang, S. J., Lycopene depresses glutamate release through inhibition of voltage-dependent Ca(2+) entry and protein kinase C in rat cerebrocortical nerve terminals. Can J Physiol Pharmacol 2018, 96 (5), 479-484.
41. Lu, C. L.; Shyu, J. F.; Wu, C. C.; Hung, C. F.; Liao, M. T.; Liu, W. C.; Zheng, C. M.; Hou, Y. C.; Lin, Y. F.; Lu, K. C., Association of Anabolic Effect of Calcitriol with Osteoclast-Derived Wnt 10b Secretion. Nutrients 2018, 10 (9).
42. Li, H. J.; Wu, N. L.; Lee, G. A.; Hung, C. F., The Therapeutic Potential and Molecular Mechanism of Isoflavone Extract against Psoriasis. Sci Rep 2018, 8 (1), 6335.
43. Hu, J. M.; Shen, C. J.; Chou, Y. C.; Hung, C. F.; Tian, Y. F.; You, S. L.; Chen, C. Y.; Hsu, C. H.; Hsiao, C. W.; Lin, C. Y.; Sun, C. A., Risk of colorectal cancer in patients with periodontal disease severity: a nationwide, population-based cohort study. Int J Colorectal Dis 2018, 33 (3), 349-352.
44. Hou, Y. C.; Wu, C. C.; Liao, M. T.; Shyu, J. F.; Hung, C. F.; Yen, T. H.; Lu, C. L.; Lu, K. C., Role of nutritional vitamin D in osteoporosis treatment. Clin Chim Acta 2018, 484, 179-191.
45. Fang, J. Y.; Huang, T. H.; Hung, C. F.; Huang, Y. L.; Aljuffali, I. A.; Liao, W. C.; Lin, C. F., Derivatization of honokiol by integrated acetylation and methylation for improved cutaneous delivery and anti-inflammatory potency. Eur J Pharm Sci 2018, 114, 189-198.
46. Alalaiwe, A.; Hung, C. F.; Leu, Y. L.; Tahara, K.; Chen, H. H.; Hu, K. Y.; Fang, J. Y., The active compounds derived from Psoralea corylifolia for photochemotherapy against psoriasis-like lesions: The relationship between structure and percutaneous absorption. Eur J Pharm Sci 2018, 124, 114-126.
47. Yang, C. C.; Hung, C. F.; Chen, B. H., Preparation of coffee oil-algae oil-based nanoemulsions and the study of their inhibition effect on UVA-induced skin damage in mice and melanoma cell growth. Int J Nanomedicine 2017, 12, 6559-6580.
48. Lin, M. H.#; Hung, C. F.#; Aljuffali, I. A.; Sung, C. T.; Huang, C. T.; Fang, J. Y., Cationic amphiphile in phospholipid bilayer or oil-water interface of nanocarriers affects planktonic and biofilm bacteria killing. Nanomedicine 2017, 13 (2), 353-361.
49. Hung, C. F.; Hsiao, C. Y.; Hsieh, W. H.; Li, H. J.; Tsai, Y. J.; Lin, C. N.; Chang, H. H.; Wu, N. L., 18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts. PLoS One 2017, 12 (8), e0182981.
50. Hsieh, P. W.; Hung, C. F.; Lin, C. H.; Huang, C. W.; Fang, J. Y., Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation. Eur J Pharm Biopharm 2017, 114, 154-163.
51. Chang, C. Y.; Hung, C. F.; Huang, S. K.; Kuo, J. R.; Wang, S. J., Amiodarone reduces depolarization-evoked glutamate release from hippocampual synaptosomes. J Pharmacol Sci 2017, 133 (3), 168-175.
52. Chang, C. J.; Lin, J. F.; Hsiao, C. Y.; Chang, H. H.; Li, H. J.; Chang, H. H.; Lee, G. A.; Hung, C. F.*, Lutein Induces Autophagy via Beclin-1 Upregulation in IEC-6 Rat Intestinal Epithelial Cells. Am J Chin Med 2017, 45 (6), 1273-1291.
研討會論文
期間 內容
Hung CF, Chan CM, Li HJ. The inhibitory effects of gold nanoparticles on VEGF-A-induced cell migration in choroid-retina endothelial cells. PT11-07, 3-8 November, 2019, Nago, Okinawa, Japan
Wu NL, Lu PH, Lin WW, Huang DY, Gu CH, Hung CF. Spleen tyrosine kinase regulates UVB-induced inflammation in skin. The 6th Continental Congress of Dermatology. The 13th Annual Meeting of the Taiwanese Society for Investigative Dermatology. 2018. 16-18. Taipei, Taiwan. (Oral, T1)
Chiu, LY, Wu NL, Hung CF, Lin WW. PARP-1 involves in regulation of UVB-induced inflammation in skin via DNA repair and NLRP3 inflammasome activation in keratinocytes and macrophages. The 6th Continental Congress of Dermatology. The 13th Annual Meeting of the Taiwanese Society for Investigative Dermatology. 2018. 16-18. Taipei, Taiwan (P05)
Hung KL, Hung CF, Lin JT. Visiting tour of medical humanities museum for non-medical university students Taiwan Association of Medical Education 2018 Annual Meeting and Conference. 2018.11.13. NTU, Taipei, Taiwan
Hung CF. Evaluating the protective effects of nature products for barrier care. International Cosmetic-Tech Conference & Exhibition. 2018.9.14-15 Kaohsiung, Taiwan (Oral)
研究計畫
期間 主持人 計畫名稱 贊助單位 贊助金額 職稱
歷年科技部專題研究計畫:
1. 台灣天然物標靶多型免疫反應在異位皮膚炎治療與預防之研究 (110.8~113.7)(MOST110-2320-B-030 -004 -MY3)(三年期)
2. 中草藥成分及其萃取物於過敏性皮膚疾病之治療策略與應用(107.8~110.7)(MOST107-2320-B-030-003-MY3)(三年期)
3. 中草藥成分及其萃取物對發炎性皮膚疾病之治療潛力及其分子作用機轉探討 (104.8~107.7)(MOST104-2320-B-030-008-MY3 )(三年期)
4. 中草藥之類胡蘿蔔素與類黃酮成分應用在皮膚發炎及屏障損傷相關疾病之研究及機轉探討(101.8~104.7)(101-2320-B-030-005-MY3)(三年期)
5. 天然物成分對皮膚結構保護之研究(100.8~101.7)(NSC100-2320-B-030-002)
6. 傳統中草藥萃取純成份及複合配方抗皮膚及眼睛老化之探索 (97.8~100.7)(97-2320-B-030-001-MY3)(三年期)
7. 傳統中藥成份在皮膚保護與吸收之評估與應用 (95.8~97.7)(NSC 95-2320-B-030-007-MY2)(二年期)
8. 微米級和奈米級茄紅素粉末對皮膚保護功效的研究(93.8~96.7) (NSC-93-2745-B-030-005-URD,NSC-94-2745-B-030004-URD)(三年期)
9. 評估國內分離之天然物成分及其衍生物在皮膚保養之應用-經皮吸收與有效性機轉之探討(NSC 94-2320-B030-008)
10. 研究與評估類黃鹼素經皮吸收能力及護膚功效(結構與活性分析)(NSC 93-2320-B-030-014)
11. 評估並改善植物多酚化合物經皮吸收及協同功效之研究(NSC 92-2320-B-030-011)
12. 抗氧化劑及維他命經皮吸收之評估與改善(NSC 91-2320-B-030-010)
其他教學經驗
其他教學經驗
期間 內容
全人教育課程中心/化妝品科學與應用
基礎醫學研究所/老化特論/實驗藥理學
基礎醫學研究所/藥理學特論
臨床心理系/藥理學
醫學系/PBL/Tutor
醫學系/心臟血管藥理學
護理系、呼吸治療系/藥理學
護理研究所/進階心臟血管藥理學