學歷
學校 系所 學位
國立台灣大學 生化科學研究所 博士
國立台灣大學 生化暨分子生物研究所 碩士
經歷
期間 單位 部門 職稱
中央研究院 基因體研究中心 博士後研究員
中央研究院 生物化學研究所 博士後研究員
專長
生化學科
學術著作
期刊論文
期間 內容
1. Liang-Jie Wang, Chie-Pein Chen, Yun-Shien Lee, Pui-Sze Ng, Geen-Dong Chang, Yu-Hsuan Pao, Hsiao-Fan Lo, Chao-Hsiang Peng, Mei-Leng Cheong & Hungwen Chen. Functional antagonism between ΔNp63 and GCM1 regulates human trophoblast stemness and differentiation. Nature Communications 13(1):1626 (2022)
2. Liang-Jie Wang, Hsiao-Fan Lo, Cheng-Fu Lin, Pui-Sze Ng, Yi-Hung Wu, Yun-Shien Lee, Mei-Leng Cheong, and Hungwen Chen. SFRP3 negatively regulates placental extravillous trophoblast cell migration mediated by the GCM1-WNT10B-FZD7 axis. FASEB J. 33:314-326 (2019)
3. Yueh-Ho Chiu, Ming-Ren Yang, Liang-Jie Wang, Ming-Hon Chen, Geen-Dong Chang and Hungwen Chen. New insights into the regulation of placental growth factor gene expression by the transcription factors GCM1 and DLX3 in human placenta. J Biol Chem. 293:9801-9811 (2018)
4. Hsiao-Fan Lo, Ching-Yen Tsai, Chie-Pein Chen, Liang-Jie Wang, Yun-Shien Lee, Chia-Yu Chen, Chung-Tiang Liang, Mei-Leng Cheong and Hungwen Chen. Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion. J Pathol. 241:324-336 (2017)
5. Mei-Leng Cheong, Liang-Jie Wang, Pei-Yun Chuang, Ching-Wen Chang, Yun-Shien Lee, Hsiao-Fan Lo, Ming-Song Tsai, Hungwen Chen. A positive feedback loop between glial cells missing 1 (GCM1) and human chorionic gonadotropin (hCG) regulates placental hCG expression and cell differentiation. Molecular and Cellular Biology, 36:197-209 (2015)
6. Chih-Lung Chen, Liang-Jie Wang, Yu-Ting Yan, Hung-Wei Hsu, Hong-Lin Su, Fang-Pei Chang, Patrick C.H. Hsieh, Shiaw-Min Hwang, Chia-Ning Shen. Cyclin D1 acts as a barrier to pluripotent reprogramming by promoting neural progenitor fate commitment. FEBS LETTERS, 588:4008-17 (2014).
7. Liang-Jie Wang, Mei-Leng Cheong, Yun-Shien Lee, Ming-Ting Lee, Hungwen Chen. High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion. Molecular and Cellular Biology, 32:3707-17 (2012)
8. Ching-Yeu Liang*, Liang-Jie Wang*, Chie-Pein Chen, Liang-Fu Chen, Yee-Hsiung Chen, Hungwen Chen. GCM1 regulation of the expression of syncytin 2 and its cognate receptor MFSD2A in human placenta. Biology of Reproduction, 83:387-95 (2010). (* Co-first author)
9. Meng-Hsiu Chiang, Feng-Yu Liang, Chie-Pein Chen, Ching-Wen Chang, Mei-Leng Cheong, Liang-Jie Wang, Ching-Yeu Liang, Fang-Yu Lin, Chih-Chine Chou, Hungwen Chen. Mechanism of hypoxia-induced GCM1 degradation: implications for the pathogenesis of preeclampsia. J Biol Chem. 284: 17411-9(2009)
研究計畫
期間 主持人 計畫名稱 贊助單位 贊助金額 職稱
2024/02/01~2027/01/31 鑑定調控人類絨毛外滋養層細胞分化的一新奇GCM1/ADM/ADAM8軸線及其特性探討(113-2314-B-030 -002 -MY3) 國科會專題研究計畫