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TSAI, YI-JU
Professor
065735@mail.fju.edu.tw
Education
Ph.D., Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University

Experience
2016.08 - 2021.07 Director, Graduate Institute of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University
2015.08 - 2016.07 Director, Graduate Institute of Basic Medicine, College of Medicine, Fu Jen Catholic University
2014.08 - 2015.07 Director, Center for Medical Education, College of Medicine, Fu Jen Catholic University
2015.08 - present Professor, School of Medicine, College of Medicine, Fu Jen Catholic University
2011.02 - 2015.07 Associate Professor, School of Medicine, College of Medicine, Fu Jen Catholic University
2005.08 - 2011.01 Assistant Professor, School of Medicine, College of Medicine, Fu Jen Catholic University
2004.02 - 2005.07 Teaching Assistant, Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University

Specialty

Anatomy
Neuroanatomy
Neuroscience
Neuropathy

　Author
Journal Paper

1. Chun-Ta Huang、Seu-Hwa Chen、Chi-Fen Chang、Shih-Chang Lin、June-Horng Lue、Yi-Ju Tsai* (2020) Melatonin reduces neuropathic pain behavior and glial activation through MT2 melatonin receptor modulation in a rat model of lysophosphatidylcholine-induced demyelination neuropathy. Neurochemistry International

2. Chun-Ta Huang、June-Horng Lue、Tong-Hong Cheng、Yi-Ju Tsai* (2020) Glycemic control with insulin attenuates sepsis-associated encephalopathy by inhibiting glial activation via the suppression of the nuclear factor kappa B and mitogen-activated protein kinase signaling pathways in septic rats. Brain Research 1738:146822.

3. Chun-Ta Huang、Yi-Ju Tsai、Chao-Chi Ho*、Chong-Jen Yu (2019) Radial endobronchial ultrasound-guided transbronchial biopsy for peripheral pulmonary malignancy: biopsy- or brushing-first? BMC Pulmonary Medicine 19(1):193.

4. Te-Wei Ho、Chun-Ta Huang*、Yi-Ju Tsai、Angela Shin-Yu Lien、Feipei Lai、Chong-Jen Yu (2019) Metformin use mitigates the adverse prognostic effect of diabetes mellitus in chronic obstructive pulmonary disease. Respiratory Research 20(1):69.

5. Chun-Ta Huang, Seu-Hwa Chen, Shih-Chang Lin, Wei-Ting Chen, June-Hog Lue, Yi-Ju Tsai*. (2018) Erythropoietin reduces nerve demyelination, neuropathic pain behavior and microglial MAPKs activation through erythropoietin receptors on schwann cells in a rat model of peripheral neuropathy. GLIA

6. Chun-Ta Huang, Seu-Hwa Chen, June-Hog Lue, Chi-Fen Chang, Wen-Hsin Wen, Yi-Ju Tsai*. (2016) Neurosteroid allopregnanolone suppresses median nerve injury-induced mechanical hypersensitivity and glial extracellular signal-regulated kinase activation through γ-aminobutyric acid type A receptor modulation in the rat cuneate nucleus. Anesthesiology 125:1202-1218.

7. Melissa C. Lipford, Kannan Ramar, Yao-Jen Liang, Chii-Wann Lin, Yun-Ting Chao, Jen An, Chih-Hsien Chiu, Yi-Ju Tsai, Chih-Hung Shu, Fei-Peng Lee, Rayleigh Ping-Ying Chiang*. (2016) Serotnin as a possible biomarker in obstructive sleep apnea. Sleep Medicine Reviews 28:125-132.

8. Chun-Ta Huang, Yi-Ju Tsai*. (2016) Docosahexaenoic acid confers analgesic effects after median nerve injury via inhibition of c-Jun N-terminal kinase activation in microglia. Joual of Nutritional Biochemistry 29:97-106.

9. Chun-Ta Huang, Yi-Ju Tsai, Pi-Ru Tsai, Chong-Jen Yu, Wen-Je Ko*. (2015) Epidemiology and outcome of severe sepsis and septic shock in surgical intensive care units in Northe Taiwan. Medicine 94(47):e2136.

10. Te-Wei Ho, Yi-Ju Tsai, Sheng-Yuan Ruan, Chun-Ta Huang*, Feipei Lai, Chong-Jen Yu. The HINT Study Group (2014) In-hospital and one-year mortality and their predictors in patients hospitalized for first-ever chronic obstructive pulmonary disease exacerbations: a nationwide population-based study. PLoS One 9(12), e114866.

11. Jiann-Hog Yeh, Chun-Ta Huang*, Chia-Hsiung Liu, Sheng-Yuan Ruan, Yi-Ju Tsai, Ying-Chun Chien, Ching-Yao Yang, Chun-Kai Huang, Chia-Lin Hsu, Lu-Cheng Kuo, Pei-Lin Lee, Shih-Chi Ku, Ping-Hung Kuo, Chong-Jen Yu. The HINT Study Group (2014) Cautious application of pleural N-terminal pro-B-type natriuretic peptide in diagnosis of congestive heart failure pleural effusions among critically ill patients. PLoS One 9(12), e115301.

12. Chun-Ta Huang, Rayleigh Ping-Ying Chiang, Chih-Li Chen, Yi-Ju Tsai*. (2014) Sleep deprivation aggravates median nerve injury-induced neuropathic pain and enhances microglial activation by suppressing melatonin secretion. Sleep 37(9), 1513-1523.

13. Chun-Ta Huang*, Hsien-Ho Lin, Sheng-Yuan Ruan, Meng-Sui Lee, Yi-Ju Tsai, Chong-Jen Yu. (2014) Efficacy and adverse events of high frequency oscillatory ventilation in adult patients with acute respiratory distress syndrome: a meta-analysis. Critical Care 18(3), R102.

14. Chun-Ta Huang, Li-Na Lee, Chao-Chi Ho, Chin-Chung Shu, Sheng-Yuan Ruan, Yi-Ju Tsai, Jann-Yuan Wang*, Chong-Jen Yu. (2014) High serum levels of procalcitonin and soluble TREM-1 correlated with poor prognosis in pulmonary tuberculosis. Joual of Infection 68(5), 440-447.

15. Chun-Ta Huang*, Yi-Ju Tsai, Jou-Wei Lin, Sheng-Yuan Ruan, Huey-Dong Wu, Chong-Jen Yu .(2014) Application of heart-rate variability in patients undergoing weaning from mechanical ventilation. Critical Care 18(1), R21.

16. Shih-Ping Hung, Ming-Jen Sheu, Ming-Chieh Ma, Jui-Ting Hu, Ya-Yun Sun, Chin-Cheng Lee, Yuan-Chiang Chung, Yi-Ju Tsai, Jing-Yuan Wang, Chih-Li Chen*. (2014) Runx1-deficient afferents impair visceral nociception, exacerbating dextran sodium sulfate-induced colitis. Brain Behavior and Immunity 35, 96-106.

17. Chun-Ta Huang, Yi-Ju Tsai, Pi-Ru Tsai, Wen-Je Ko*. (2013) Extracorporeal membrane oxygenation resuscitation in adult patients with refractory septic shock. Joual of Thoracic and Cardiovascular Surgery 146(5), 1041-1046.

18. Shih-Chang Lin, Yi-Ju Tsai, Chun-Ta Huang*, Yao-Wen Kuo, Sheng-Yuan Ruan, Yu-Chung Chuang, Chong-Jen Yu. (2013) Prognostic value of plasma N-terminal pro B-type natriuretic peptide levels in pneumonia patients requiring intensive care unit admission. Respirology 18(6), 933-941.

19. Hsin-Ying Wang, Yi-Ju Tsai, Seu-Hwa Chen, Chi-Te Lin, June-Hog Lue*. (2013) Lysophosphatidylcholine causes neuropathic pain via the increase of neuronal nitric oxide synthase in the dorsal root ganglion and cuneate nucleus. Pharmacology Biochemistry and Behavior 106, 47-56.

20. Yi-Ju Tsai, Kannan Ramar, Yao-Jen Liang, Po-Han Chiu, Nelson Powell, Chao-Yun Chi, Tzu-Chen Lung, Wesley Wen-Yang Lin, Po-Jung Tseng, Ming-Ying Wu, Kuan-Chiao Chien, Edward M. Weaver, Fei-Peng Lee, Chia-Mo Lin, Kuang-Chao Chen, Rayleigh Ping-Ying Chiang*. (2013) Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome. Sleep Medicine Reviews 17(2), 161-168.

21. Rayleigh Ping-Ying Chiang, Chun-Ta Huang, Yi-Ju Tsai*. (2013) Melatonin reduces median nerve injury-induced mechanical hypersensitivity via inhibition of microglial p38 mitogen-activated protein kinase activation in rat cuneate nucleus. Joual of Pineal Research 54(2), 232-244.

22. Chun-Ta Huang, Sheng-Yuan Ruan, Wei-Yu Liao, Yao-Wen Kuo, Chi-Ying Lin, Yi-Ju Tsai, Chao-Chi Ho*, Chong-Jen Yu. (2012) Risk factors of pneumothorax after endobronchial ultrasound-guided tansbronchial biopsy for peripheral lung lesions. PLoS One 7(11), e49125.

23. Chun-Ta Huang, Yi-Ju Tsai, Wei-Yu Liao, Pei-Chen Wu, Chao-Chi Ho*, Chong-Jen Yu, Pan-Chyr Yang. (2012) Endobronchial ultrasound-guided transbronchial biopsy of peripheral pulmonary lesions: how many specimens are necessary? Respiration 84(2), 128-134.

24. Seu-Hwa Chen, Yi-Ju Tsai, Chi-Te Lin, Hsin-Ying Wang, Shin-Fang Li, June-Hog Lue*. (2012) Changes in GABA and GABAB receptor expressions are involved in neuropathy in the rat cuneate nucleus following median nerve transection. Synapse 66(6), 561-572.

25. Chun-Ta Huang, Yi-Ju Tsai, Huey-Dong Wu, Jann-Yuan Wang*, Chong-Jen Yu, Li-Na Lee, Pan-Chyr Yang. (2012) Impact of non-tuberculous mycobacteria on pulmonary function decline in chronic obstructive pulmonary disease. Inteational Joual of Tuberculosis and Lung Disease 16(4), 539-545.

26. Yi-Ju Tsai*, Chun-Ta Huang, Shih-Chang Lin, Jiann-Hog Yeh. (2012) Effects of regional and whole-body hypothermic treatment before and after median nerve injury on neuropathic pain and glial activation in rat cuneate nucleus. Anesthesiology 116(2), 415-431.

27. Seu-Hwa Chen, Yi-Ju Tsai, Hsin-Ying Wang, Chi-Te Lin, Shin-Fang Li, June-Hog Lue*. (2012) Decreases of glycine receptor expression induced by median nerve injury in the rat cuneate nucleus contribute to NPY release and c-Fos expression. Life Sciences 90(7-8), 278-288.

28. Hsin-Ying Wang, Yi-Ju Tsai, Seu-Hwa Chen, Chi-Te Lin, June-Hog Lue*. (2012) Nitric oxide implicates c-Fos expression in the cuneate nucleus following electrical stimulation of the transected median nerve. Neurochemical Research 37(1), 84-95.

29. Chi-Te Lin, Yi-Ju Tsai, Hsin-Ying Wang, Seu-Hwa Chen, Tzu-Yu Lin, June-Hog Lue*. (2012) Pre-emptive treatment of lidocaine attenuates neuropathic pain and reduces pain-related biochemical markers in the rat cuneate nucleus in median nerve chronic constriction injury model. Anesthesiology Research and Practice 2012, 1-9.

30. Shih-Chang Lin, Jiann-Hog Yeh, Chih-Li Chen, Shiu-Huey Chou, Yi-Ju Tsai*. (2011) Effects of local lidocaine treatment before and after median nerve injury on mechanical hypersensitivity and microglia activation in rat cuneate nucleus. European Joual of Pain 15(4), 359-367.

31. Yuan-Chiang Chung, Yi-Ju Tsai, Ting-Ying Shiu, Ya-Yun Sun, Pin-Fang Wang, Chih-Li Chen*. (2011) Screening large numbers of expression pattes of transcription factors in late stages of the mouse thymus. Gene Expression Pattes 11(1-2), 84-92.

32. Chun-Ta Huang, Yi-Ju Tsai, Jun-Yu Fan, Shih-Chi Ku*, Chong-Jen Yu. (2010) Cryptococcosis and tuberculosis co-infection at a university hospital in Taiwan, 1993-2006. Infection 38(5), 373-379.

33. Chi-Te Lin, Yi-Ju Tsai, Seu-Hwa Chen, Hsin-Ying Wang, Lung-Huang Lin, June-Hog Lue*. (2010) Early expression of injury-induced neuropeptide Y in primary sensory neurons and the cuneate nucleus in diabetic rats with median nerve transection. Joual of Chemical Neuroanatomy 40(2), 102-111.

34. Ming-Tzer Lin, Yi-Ju Tsai, Chun-Ta Huang*. (2010) Right-sided cardiophrenic mass in an older woman. American Family Physician 82(8), 971-972.

35. Chun-Ta Huang, Rouh-Fang Yen, Mei-Fang Cheng, Ya-Chieh Hsu, Pin-Fei Wei, Yi-Ju Tsai, Meng-Feng Tsai, Jin-Yuan Shih*, Chih-Hsin Yang, Pan-Chyr Yang. (2010) Correlation of F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value and EGFR mutations in advanced lung adenocarcinoma. Medical Oncology 27(1), 9-15.

36. Jiann-Jy Chen, June-Hog Lue, Lung-Huang Lin, Chun-Ta Huang, Rayleigh Ping-Ying Chiang, Chih-Li Chen, Yi-Ju Tsai*. (2010) Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury. Pain 148(1), 158-166.

Conference Paper
Shih-Hsin Chang Chien、Tzu-Meng Yang、Dorji Harnod、Tun-Hui Chung、Yi-Ju Tsai，"Gross anatomy dissection-assisted ultrasound learning: Focusing on heart and liver"，The 34th Joint Annual Conference of Biomedical Science，Taipei，Taiwan，2019
Ko-Yen Huang、Yi-Ju Tsai，"Electroacupuncture confers analgesic effects in a rat model of neuropathic pain by inhibiting expression of inflammatory cytokines"，The 32th Joint Annual Conference of Biomedical Science，Taipei，Taiwan，2017
Rayleigh Ping-Ying Chiang、Yi-Ju Tsai，"Abnormal afferent nerve endings in the uvulae of patients with obstructive sleep apnea"，The 24th Annual Meeting of the Associated Professional Sleep Societies, LLC，San Antonio，Texas，U.S.A.，2010
Chun-Ta Huang、Yi-Ju Tsai，"Amelioration of peripheral neuropathy by implantation of neural stem cells in an animal model"，The 2nd Pan Pacific Symposium on Stem Cells Research，Taichung，Taiwan，2009 (Best Poster Award)